No Longer Human is a harrowing psychological drama manga that adapts Osamu Dazai’s semi-autobiographical novel into a visually disturbing exploration of alienation, self-destruction, and the inability to connect with society, following Yozo Oba, a man who masks his inner terror and emptiness with humor and performance while slowly descending into addiction, moral collapse, and despair as he fails to understand or live up to the expectations of being “human,” unfolding through episodic relationships, abuse, and self-sabotage that expose themes of depression, shame, social hypocrisy, and the crushing weight of existence, delivering an unflinching and deeply uncomfortable narrative that strips away romanticism to confront mental illness and nihilism head-on, widely regarded as one of the most devastating works in Japanese literature and manga for its raw honesty and emotional brutality, also known as No Longer Human manga, Ningen Shikkaku, 人間失格, Osamu Dazai No Longer Human, Junji Ito No Longer Human, existential psychological manga, depression literature manga, and dark autobiographical manga.