Fabricant 100 takes place in a world where "Fabricants," artificial beings crafted from human parts, possess inhuman strength and beauty but lack true humanity. Humans were often harvested for their bodies until genius doctor Ashibi Yao created Fabricant No. 100, the strongest and most intelligent of them all. Bound by a contract, No. 100 becomes Ashibi’s partner as he seeks revenge against the Fabricants who killed his family. Together, they hunt down the remaining Fabricants ranked from No. 1 to No. 99. Their journey blurs the line between creator and creation, monster and human, loyalty and manipulation, as Ashibi questions what it truly means to be human while No. 100 slowly develops desires that go beyond her design.